MAPK-IN-1
Product Specifications
UNSPSC Description
MAPK-IN-1 (Compound 2) is a MAPK signaling pathway inhibitor. MAPK-IN-1 exhibits AChE inhibitory activity with an IC50 of 23.84 μM. MAPK-IN-1 shows anti-neuroinflammatory and neuroprotective activity and can be used for Alzheimer's disease research[1].
Target Antigen
Cholinesterase (ChE); ERK; JNK; p38 MAPK; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation;MAPK/ERK Pathway;Neuronal Signaling;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mapk-in-1.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1CCC(C2=C(C3=C(C(C2=O)=O)[C@@H](C)CO3)C=C4)=C4C1(C)C
Molecular Weight
310.34
References & Citations
[1]Wu JS, et al. The oxygenated products of cryptotanshinone by biotransformation with Cunninghamella elegans exerting anti-neuroinflammatory effects by inhibiting TLR 4-mediated MAPK signaling pathway. Bioorg Chem. 2020 Nov;104:104246.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146195/MAPK-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146195/MAPK-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2470587-69-8
Available Sizes
Curated Selection
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