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MAPK-IN-1

MAPK-IN-1 (Compound 2) is a MAPK signaling pathway inhibitor. MAPK-IN-1 exhibits AChE inhibitory activity with an IC50 of 23.84 μM. MAPK-IN-1 shows anti-neuroinflammatory and neuroprotective activity and can be used for Alzheimer's disease research[1].

Product Specifications

CAS Number

[2470587-69-8]

UNSPSC

12352005

Target

Cholinesterase (ChE) ; ERK; JNK; p38 MAPK; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mapk-in-1.html

Purity

95.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1CCC(C2=C(C3=C(C(C2=O)=O)[C@@H](C)CO3)C=C4)=C4C1(C)C

Molecular Formula

C19H18O4

Molecular Weight

310.34

References & Citations

[1]Wu JS, et al. The oxygenated products of cryptotanshinone by biotransformation with Cunninghamella elegans exerting anti-neuroinflammatory effects by inhibiting TLR 4-mediated MAPK signaling pathway. Bioorg Chem. 2020 Nov;104:104246.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

AChE; TLR4

Available Sizes

Curated Selection

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