Interleukin-6Rα/CD126 Rabbit Monoclonal Antibody

<strong>Interleukin-6RŒ±/CD126 Rabbit Monoclonal Antibody</strong>_x000D_ <strong>Catalog number:</strong> B2017611_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 25 µL_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> SOLUTION_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80¬∞C_x000D_ <strong>Keywords:</strong> IL-6RŒ±, Interleukin-6 Receptor Subunit Œ±_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Kimura T, Sakabe H, Tanimukai S, Abe T, Urata Y, Yasukawa K, Okano A, Taga T, Sugiyama H, Kishimoto T, Sonoda Y. Simultaneous activation of signals through gp130, c-kit, and interleukin-3 receptor promotes a trilineage blood cell production in the absence of terminally acting lineage-specific factors Blood. 1997 Dec 15;90(12):4767-78._x000D_ 2: Xu C, Rafique A, Potocky T, Paccaly A, Nolain P, Lu Q, Iglesias-Rodriguez M, St John G, Nivens MC, Kanamaluru V, Fairhurst J, Ishii T, Maldonado R, Choy E, Emery P. Differential Binding of Sarilumab and Tocilizumab to IL-6RŒ± and Effects of Receptor Occupancy on Clinical Parameters J Clin Pharmacol. 2021 May;61(5):714-724._x000D_ 3: Scott LJ. Sarilumab: First Global Approval Drugs. 2017 Apr;77(6):705-712._x000D_ 4: Lipsky PE. Interleukin-6 and rheumatic diseases Arthritis Res Ther. 2006;8 Suppl 2(Suppl 2):S4._x000D_ 5: Assier E, Boissier MC, Dayer JM. Interleukin-6: from identification of the cytokine to development of targeted treatments Joint Bone Spine. 2010 Dec;77(6):532-6._x000D_ 6: Chou CC, Hua KT, Chen MW, Wu CJ, Hsu CH, Wang JT, Hsiao M, Wei LH. Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6RŒ± to inhibit IL-6/ IL-6RŒ±/gp130 hexameric signaling complex formation MAbs. 2022 Jan-Dec;14(1):2029675._x000D_ 7: Lee EB, Daskalakis N, Xu C, Paccaly A, Miller B, Fleischmann R, Bodrug I, Kivitz A. Disease-Drug Interaction of Sarilumab and Simvastatin in Patients with Rheumatoid Arthritis Clin Pharmacokinet. 2017 Jun;56(6):607-615._x000D_ 8: Chehboun S, Labrecque-Carbonneau J, Pasquin S, Meliani Y, Meddah B, Ferlin W, Sharma M, Tormo A, Masson JF, Gauchat JF. Epstein-Barr virus-induced gene 3 (EBI3) can mediate IL-6 trans-signaling J Biol Chem. 2017 Apr 21;292(16):6644-6656._x000D_ 9: Ma X, Ding J, Min H, Wen Y, Gao Q. Protective role of low-dose TGF-Œ≤1 in early diabetic nephropathy induced by streptozotocin Int Immunopharmacol. 2013 Nov;17(3):752-8._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/24297381">10: Huizinga TW, Fleischmann RM, Jasson M, Radin AR, van Adelsberg J, Fiore S, Huang X, Yancopoulos GD, Stahl N, Genovese MC. Sarilumab, a fully human monoclonal antibody against IL-6RŒ± in patients with rheumatoid arthritis and an inadequate response to methotrexate: efficacy and safety results from the randomised SARIL-RA-MOBILITY Part A trial Ann Rheum Dis. 2014 Sep;73(9):1626-34. </a>_x000D_ _x000D_ <strong>Products Related to Interleukin-6RŒ±/CD126 Rabbit Monoclonal Antibody can be found at</strong> <a href="https://moleculardepot.com/product-category/Antibodies/"> Antibodies</a>