Tecastemizole
Tecastemizole (Norastemizole), a major metabolite of Astemizole, is a potent and selective H1 receptor antagonist. Tecastemizole shows anti-inflammatory activities[1].
Product Specifications
CAS Number
[75970-99-9]
Product Name Alternative
Norastemizole
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tecastemizole.html
Concentration
10mM
Purity
99.22
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1=CC=C(CN2C3=CC=CC=C3N=C2NC4CCNCC4)C=C1
Molecular Formula
C19H21FN4
Molecular Weight
324.40
Precautions
H315, H319, H320
References & Citations
[1]Lever R, et al. Effect of tecastemizole on pulmonary and cutaneous allergic inflammatory responses. Clin Exp Allergy. 2007 Jun;37 (6) :909-17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H1 Receptor
Available Sizes
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