Umeclidinium-d5 (bromide)
Umeclidinium-d5 (bromide) is the deuterium labeled Umeclidinium bromide. Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.
Product Specifications
Product Name Alternative
GSK573719A-d5
UNSPSC
12352005
Target
Isotope-Labeled Compounds; mAChR
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
OC(C12CC[N+](CC2)(CCOCC3=C(C([2H])=C(C([2H])=C3[2H])[2H])[2H])CC1)(C4=CC=CC=C4)C5=CC=CC=C5.[Br-]
Molecular Formula
C29H29D5BrNO2
Molecular Weight
513.52
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Salmon M, et al. Pharmacological characterization of GSK573719 (umeclidinium) : a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases. J Pharmacol Exp Ther. 2013 May;345 (2) :260-70.|[3]Cazzola M, et al. Pharmacology and therapeutics of bronchodilators. Pharmacol Rev. 2012 Jul;64 (3) :450-504.|[4]Calzetta L, et al. Pharmacological characterization of the interaction between umeclidinium and vilanterol in human bronchi. Eur J Pharmacol. 2017 Jul 14. pii: S0014-2999 (17) 30470-3.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
MAChR1; mAChR5
Available Sizes
Frequently Asked Questions
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