Miriplatin

Miriplatin (SM-11355) is a chemotherapy agent which belongs to the class of alkylating agents.

Product Specifications

CAS Number

[141977-79-9]

Product Name Alternative

SM-11355

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Miriplatin.html

Purity

98.0

Solubility

Acetone : < 1 mg/mL (ultrasonic)|DMF : < 1 mg/mL|H2O : < 0.1 mg/mL

Smiles

NC1CCCCC1N.[O-]C(CCCCCCCCCCCCC)=O.[O-]C(CCCCCCCCCCCCC)=O.[Pt+2]

Molecular Formula

C34H68N2O4Pt

Molecular Weight

764.00

Precautions

H302, H315, H319, H335

References & Citations

[1]Kishimoto S, et al. Antitumor effects of a novel lipophilic platinum complex (SM-11355) against a slowly-growing rat hepatic tumor after intra-hepatic arterial administration. Biol Pharm Bull. 2000 Mar;23 (3) :344-8.|[2]Hanada M, et al. Intra-hepatic arterial administration with miriplatin suspended in an oily lymphographic agent inhibits the growth of tumors implanted in rat livers by inducing platinum-DNA adducts to form and massive apoptosis. Cancer Chemother Pharmacol. 2009 Aug;64 (3) :473-83.