Enpp-1-IN-2
Enpp-1-IN-2 (Compound C) is a potent ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) inhibitor with IC50 values of 0.26, 0.48 and 2.0 μM evaluated by means of TG-mAMP, pNP-TMP, and ATP assays, respectively. TG (Tokyo Green) -mAMP: a newly synthesized sensitive ENPP1 fluorescence probe[1].
Product Specifications
CAS Number
[2378640-92-5]
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/enpp-1-in-2.html
Purity
99.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=NC2=NC=NN2C(N(C)C)=C1CC3=CC=CC(N)=C3
Molecular Formula
C15H18N6
Molecular Weight
282.34
References & Citations
[1]Kawaguchi M, et al. Development of an ENPP1 Fluorescence Probe for Inhibitor Screening, Cellular Imaging, and Prognostic Assessment of Malignant Breast Cancer. J Med Chem. 2019 Oct 24;62 (20) :9254-9269.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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