Tazobactam

Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research[1][2].

Product Specifications

CAS Number

[89786-04-9]

Product Name Alternative

CL-298741; YTR-830H

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; Beta-lactamase

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Tazobactam.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C([C@@H]([C@@](CN1N=NC=C1)(C)S([C@]2([H])C3)(=O)=O)N2C3=O)O

Molecular Formula

C10H12N4O5S

Molecular Weight

300.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Harada Y, et, al. In vitro and in vivo activities of piperacillin-tazobactam and meropenem at different inoculum sizes of ESBL-producing Klebsiella pneumoniae. Clin Microbiol Infect. 2014 Nov;20 (11) :O831-9.|[2]Higashitani F, et, al. Inhibition of beta-lactamases by tazobactam and in-vitro antibacterial activity of tazobactam combined with piperacillin. J Antimicrob Chemother. 1990 Apr;25 (4) :567-74.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

β-lactam

Citation 01

ACS Environ Au. 2025 Aug 8.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|Antimicrob Agents Chemother. 2023 Jun 15;67 (6) :e0160322.|bioRxiv. 2024 May 10.|Eur J Clin Microbiol Infect Dis. 2025 Feb;44 (2) :277-284.|Int J Antimicrob Agents. 2025 Jun 9:107551.|Int J Med Microbiol. 2021 Oct;70 (10) .|J Antimicrob Chemother. 2025 Nov 5:dkaf408.|Microbiol Spectr. 2023 Feb 14;11 (1) :e0303822.|Microbiol Spectr. 2023 Jun 15;11 (3) :e0069223.|Molecules. 2025 Mar 9;30 (6) :1224.|PLoS Pathog. 2024 Dec 31;20 (12) :e1012783.|Research Square Preprint. 2021 Aug.|Antimicrob Agents Chemother. 2024 Nov 6;68 (11) :e0077524.|Eur J Clin Microbiol Infect Dis. 2025 Mar;44 (3) :571-585.|medRxiv. 2025 Mar 13:2025.03.11.25323422.|Nat Commun. 2022 Mar 2;13 (1) :1116.