CXCR7 antagonist-1 (hydrochloride)

CXCR7 antagonist-1 hydrochloride is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 hydrochloride is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases[1].

Product Specifications

CAS Number

[2990472-61-0]

UNSPSC

12352005

Target

Adrenergic Receptor; CXCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cxcr7-antagonist-1-hydrochloride.html

Concentration

10mM

Purity

99.41

Solubility

DMSO : 350 mg/mL (ultrasonic)

Smiles

O=C(C1=NN(C2=CC=C(C=C2)F)C=C1)N[C@@H]3CN(CC3)C4=NC=CN5C4=CC=C5.[H]Cl

Molecular Formula

C21H20ClFN6O

Molecular Weight

426.87

References & Citations

[1]Junfa Fan, et al. Cxcr7 antagonists. Patent WO2014085490A1.|[2]Zhao C, et al., Infant RSV infection desensitizes β2-adrenergic receptor via CXCL11-CXCR7 signaling in airway smooth muscle. bioRxiv [Preprint]. 2025 Jan 15:2025.01.13.632772.