β-Amyloid (12-28) (TFA)

β-Amyloid (12-28) (TFA) (Amyloid β-Protein (12-28) (TFA) ) is a peptide fragment of β-amyloid protein (β1-42) . β1-42, a 42 amino acid protein , is the major component of senile plaque cores. β-Amyloid (12-28) (TFA) shows aggregation properties. β-Amyloid (12-28) (TFA) has the potential for Alzheimer’s disease research[1].

Product Specifications

Product Name Alternative

Amyloid β-Protein (12-28) (TFA) ; Amyloid Beta-Peptide (12-28) (human) (TFA) ; β-Amyloid protein fragment (12-28) (TFA)

UNSPSC

12352209

Target

Amyloid-β

Type

Peptides

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/β-amyloid-12-28-tfa.html

Purity

99.80

Solubility

DMSO : 120 mg/mL (ultrasonic)

Smiles

CC([C@@H](C(N[C@H](C(N[C@@H](CC1=CN=CN1)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CC(N)=O)=O)CO)=O)=O)C(C)C)=O)CC(O)=O)=O)CCC(O)=O)=O)C)=O)=O)=O)C(C)C)=O)CC(C)C)=O)CCCCN)=O)CCC(N)=O)=O)=O)CC4=CN=CN4)=O)N)C.O=C(O)C(F)(F)F

Molecular Formula

C91H136N25F3O27

Molecular Weight

2069.20

References & Citations

[1]Rabanal F, et al. Structural, kinetic and cytotoxicity aspects of 12-28 beta-amyloid protein fragment: a reappraisal. J Pept Sci. 2002 Oct;8 (10) :578-88.|[2]Nikunj S Patel, et al. Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptide. Amyloid. 2008 Mar;15 (1) :5-19.