AL 8697

AL 8697 is a specific and orally active p38α MAPK inhibitor with an IC50 of 6 nM. AL 8697 displays 14-fold greater inhibition of p38α compared to p38β (IC50=82 nM), and 300-fold selectivity for p38α over a panel of 91 kinases. Anti-inflammatory activity[1].

Product Specifications

CAS Number

[1057394-06-5]

UNSPSC

12352005

Target

Autophagy; p38 MAPK

Type

Reference compound

Related Pathways

Autophagy; MAPK/ERK Pathway

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/al-8697.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1CC1)C2=CC(F)=C(C)C(C3=C(F)C4=NN=C(C(C)(C)C)N4C=C3F)=C2

Molecular Formula

C21H21F3N4O

Molecular Weight

402.41

References & Citations

[1]Balagué C, et al. Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study. Br J Pharmacol. 2012 Jun;166 (4) :1320-32.