Cephalotaxine

Cephalotaxlen ((-) -Cephalotaxine) is an alkaloid that can be isolated from Cephalotaxus fortunei, with antileukemic and antiviral activities. Cephalotaxlen has anti-ZIKV (Zika virus) activity[1][2][3].

Product Specifications

CAS Number

[24316-19-6]

Product Name Alternative

(-) -Cephalotaxine; ZINC19795976

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Flavivirus

Type

Natural Products

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/cephalotaxlen.html

Purity

99.21

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@](C(C=C(OCO2)C2=C3)=C3CCN4CCC5)([H])[C@]45C=C1OC

Molecular Formula

C18H21NO4

Molecular Weight

315.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang DZ, et al. Studies on the alkaloids of Cephalotaxus. IX. Semi-synthesis of cephalotaxine esters and their anti-leukemic activity Yao Xue Xue Bao. 1992;27 (3) :178-84.|[2]Efferth T, et al. Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jan;367 (1) :56-67.|[3]Zheng-Zong Lai, et al. Cephalotaxine inhibits Zika infection by impeding viral replication and stability. Biochem Biophys Res Commun. 2020 Feb 19; 522 (4) : 1052–1058.