Amyloid β (Human, 12-28)

<strong>Amyloid β (Human, 12-28)</strong>_x000D_ <strong>Catalog number:</strong> B2023781_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 500 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> 1955.18 g/mol_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> −20°C_x000D_ <strong>Keywords:</strong> Amyloid beta, Aβ, Amyloid precursor protein fragment, Beta-amyloid, A4 peptide, Amyloid beta peptide, Human amyloid beta, Amyloid beta (1-42), Amyloid beta (1-40)_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1. Selkoe, D. J. (2001). Alzheimer's disease: genes, proteins, and therapy. *Physiological Reviews*, 81(2), 741-766._x000D_ _x000D_ 2. Hardy, J., &amp; Selkoe, D. J. (2002). The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. *Science*, 297(5580), 353-356._x000D_ _x000D_ 3. Haass, C., &amp; Selkoe, D. J. (2007). Soluble and insoluble beta-amyloid: a key role for protofibrils in Alzheimer's disease. *The American Journal of Pathology*, 171(1), 1-4._x000D_ _x000D_ 4. Karran, E., &amp; Walker, L. (2013). The amyloid cascade hypothesis: are we poised for success? *Nature Reviews Drug Discovery*, 12(10), 751-752._x000D_ _x000D_ 5. Selkoe, D. J. (2012). Alzheimer's disease: a central role for amyloid. *Nature Reviews Neuroscience*, 13(8), 494-504._x000D_ _x000D_ 6. Shankar, G. M., et al. (2008). Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. *Nature Neuroscience*, 11(6), 756-764._x000D_ _x000D_ 7. Wang, H., et al. (2017). Amyloid-beta oligomers induce synaptic dysfunction via the activation of the NMDA receptor. *Nature Communications*, 8, 14537._x000D_ _x000D_ 8. Klyubin, I., et al. (2005). Amyloid beta protein dimer-induced synaptic dysfunction may be a key event in the pathogenesis of Alzheimer's disease. *Neurobiology of Aging*, 26(5), 691-703._x000D_ _x000D_ 9. Lesne, S., et al. (2006). A specific amyloid-beta protein assembly involved in the onset of Alzheimer's disease. *Nature*, 440(7082), 352-357._x000D_ _x000D_ 10. Cline, E. N., et al. (2018). The amyloid hypothesis at 25: progress and future directions. *Nature Reviews Neuroscience*, 19(1), 29-50._x000D_ <a href="Amyloid β (Human, 12-28)">https://pubmed.ncbi.nlm.nih.gov/?term=Amyloid β (Human, 12-28)</a>_x000D_ _x000D_ <strong>Products Related to Amyloid β (Human, 12-28) can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>