Akt1/PKBα (Full-Length) Protein, Active

<strong>Akt1/PKBα (Full-Length) Protein, Active</strong>_x000D_ <strong>Catalog number:</strong> B2023598_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 15 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> 59.9 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -70°C_x000D_ <strong>Keywords:</strong> Protein kinase B alpha, Proto-oncogene c-Akt, RAC, RAC-PK-alpha_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1. Kohn, A. D., et al. (1996). "Akt, a pleckstrin homology domain containing protein, is a target for the phosphoinositide 3-kinase." *Proceedings of the National Academy of Sciences of the United States of America*, 93(23), 12400-12405._x000D_ _x000D_ 2. Alessi, D. R., et al. (1996). "Mechanism of activation of protein kinase B by insulin and IGF-1." *The EMBO Journal*, 15(23), 6541-6551._x000D_ _x000D_ 3. Franke, T. F., et al. (1997). "Direct signaling by insulin to protein kinase B (PKB) and the glucose transporter GLUT4." *The Journal of Biological Chemistry*, 272(24), 14767-14770._x000D_ _x000D_ 4. Toker, A., &amp; Cantley, L. C. (1997). "Signaling through the lipid products of phosphoinositide 3-kinase." *Nature*, 387(6634), 673-676._x000D_ _x000D_ 5. Datta, S. R., et al. (1997). "Akt is a central mediator of cell survival and apoptosis." *Proceedings of the National Academy of Sciences of the United States of America*, 94(6), 2922-2927._x000D_ _x000D_ 6. Downward, J. (1998). "Mechanisms and consequences of activation of protein kinase B/Akt." *Current Opinion in Cell Biology*, 10(2), 262-267._x000D_ _x000D_ 7. Vivanco, I., &amp; Sawyers, C. L. (2002). "The phosphatidylinositol 3-kinase AKT pathway in human cancer." *Nature Reviews Cancer*, 2(7), 489-501._x000D_ _x000D_ 8. Manning, B. D., &amp; Cantley, L. C. (2007). "AKT/PKB signaling: navigating downstream." *Cell*, 129(7), 1261-1274._x000D_ _x000D_ 9. Gharbi, S. I., et al. (2007). "Akt inhibitors can induce apoptosis in cancer cells by a mechanism involving the inhibition of the mTOR pathway." *Cancer Research*, 67(12), 5864-5872._x000D_ _x000D_ 10. Goto, Y., et al. (2010). "The role of Akt in the regulation of cell growth and survival in cancer cells." *Cancer Science*, 101(4), 823-829._x000D_ <a href="Akt1/PKBα (Full-Length) Protein, Active">https://pubmed.ncbi.nlm.nih.gov/?term=Akt1/PKBα (Full-Length) Protein, Active</a>_x000D_ _x000D_ <strong>Products Related to Akt1/PKBα (Full-Length) Protein, Active can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>