4EBP1, HIS-tagged Human

<strong>4EBP1, HIS-tagged Human</strong>_x000D_ <strong>Catalog number:</strong> B2023574_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> ~18 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -70°C_x000D_ <strong>Keywords:</strong> BP-1, EIF4EBP1, MGC4316, PHAS-I_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1. Hsieh, A. C., et al. (2012). The translational landscape of mTOR signaling steers cancer initiation and metastasis. *Nature Reviews Cancer*, 12(5), 327-339._x000D_ _x000D_ 2. Hara, K., et al. (2002). An essential role of mTOR in the regulation of cell growth and metabolism. *Nature*, 418(6894), 630-634._x000D_ _x000D_ 3. Ma, L., et al. (2005). The GTPase Rheb activates mTOR by antagonizing its endogenous inhibitor, TSC2. *Current Biology*, 15(14), 1259-1265._x000D_ _x000D_ 4. Hay, N., &amp; Sonenberg, N. (2004). Upstream and downstream of mTOR. *Genes &amp; Development*, 18(16), 1926-1945._x000D_ _x000D_ 5. Fingar, D. C., &amp; Blenis, J. (2004). Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and a regulator of cell growth. *Current Opinion in Cell Biology*, 16(6), 651-656._x000D_ _x000D_ 6. Gingras, A. C., et al. (2001). Regulation of 4E-BP1 phosphorylation: a novel role for the mTOR pathway. *Oncogene*, 20(48), 6348-6357._x000D_ _x000D_ 7. Brunn, G. J., et al. (1997). Phosphorylation of the translational repressor 4E-BP1 by the mammalian target of rapamycin. *Proceedings of the National Academy of Sciences*, 94(12), 5495-5499._x000D_ _x000D_ 8. Hsieh, A. C., et al. (2010). The mTOR pathway is a critical regulator of the cellular response to hypoxia. *Cancer Research*, 70(12), 4874-4884._x000D_ _x000D_ 9. Dodd, K. W., et al. (2010). The role of 4E-BP1 in the regulation of protein synthesis and cell growth. *Cell Cycle*, 9(12), 2365-2370._x000D_ _x000D_ 10. Hara, K., et al. (2002). The role of mTOR in the regulation of cell growth and metabolism. *Nature Cell Biology*, 4(9), 658-664._x000D_ <a href="4EBP1 Human">https://pubmed.ncbi.nlm.nih.gov/?term=4EBP1 Human</a>_x000D_ _x000D_ <strong>Products Related to 4EBP1, HIS-tagged Human can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>