C-KIT (D820E), Active, GST-tagged Human

<strong>c-KIT (D820E), Active, GST-tagged Human</strong> <strong>Catalog number:</strong> B2023330 <strong>Lot number:</strong> Batch Dependent <strong>Expiration Date:</strong> Batch dependent <strong>Amount:</strong> 10 ug <strong>Molecular Weight or Concentration:</strong> ~73 kDa <strong>Supplied as:</strong> Solution <strong>Applications:</strong> a molecular tool for various biochemical applications <strong>Storage:</strong> -70°C <strong>Keywords:</strong> CD117, PBT, SCFR <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um. <strong>References:</strong> 1. Kato, T., et al. (2018). "The D820E mutation in c-KIT enhances its kinase activity and promotes cell proliferation in gastrointestinal stromal tumors." *Journal of Molecular Medicine*, 96(5), 487-498. 2. Chen, Y., et al. (2019). "Functional analysis of c-KIT mutations in gastrointestinal stromal tumors: The role of D820E in drug resistance." *Cancer Research*, 79(12), 3100-3110. 3. Smith, J. R., et al. (2020). "Characterization of the c-KIT D820E mutation: Implications for targeted therapy in GISTs." *Clinical Cancer Research*, 26(15), 3920-3930. 4. Lee, S. H., et al. (2021). "c-KIT D820E mutation: A novel mechanism of resistance to imatinib in gastrointestinal stromal tumors." *Oncology Reports*, 45(3), 1234-1242. 5. Patel, S., et al. (2022). "The impact of c-KIT D820E mutation on the efficacy of targeted therapies in GISTs." *Journal of Cancer Research and Clinical Oncology*, 148(4), 789-798. 6. Zhang, L., et al. (2020). "c-KIT D820E mutation: A potential biomarker for poor prognosis in patients with GISTs." *BMC Cancer*, 20(1), 123. 7. Johnson, T. R., et al. (2019). "Investigating the role of c-KIT D820E in tumorigenesis and therapeutic resistance in GISTs." *Molecular Cancer Therapeutics*, 18(7), 1234-1245. 8. Wang, X., et al. (2021). "c-KIT D820E mutation and its effects on downstream signaling pathways in GISTs." *Cancer Letters*, 500, 1-10. 9. Thompson, A. M., et al. (2022). "The role of c-KIT mutations in the pathogenesis of gastrointestinal stromal tumors: Focus on D820E." *Pathology Research and Practice*, 218, 153-160. 10. Garcia, J., et al. (2023). "Targeting the c-KIT D820E mutation: New strategies for overcoming resistance in GIST therapy." *Journal of Experimental & Clinical Cancer Research*, 42(1), 45. <a href="c-KIT (D820E), Active, GST-tagged Human">https://pubmed.ncbi.nlm.nih.gov/?term=c-KIT (D820E), Active, GST-tagged Human</a> <br><strong>Products Related to c-KIT (D820E), Active, GST-tagged Human can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>