Tau (K18) P301L Mutant Protein Pre-formed Fibrils

<strong>Tau (K18) P301L Mutant Protein Pre-formed Fibrils</strong> <strong>Catalog number:</strong> B2022499 <strong>Lot number:</strong> Batch Dependent <strong>Expiration Date:</strong> Batch dependent <strong>Amount:</strong> 100 µg <strong>Molecular Weight or Concentration:</strong> ~15.1 kDa <strong>Supplied as:</strong> Solution <strong>Applications:</strong> a molecular tool for various biochemical applications <strong>Storage:</strong> -80¬∞C <strong>Keywords:</strong> Tau PFFs, Tau PFF, Tau protein Pre-formed Fibrils, Tau aggregates, microtubule-associated protein Tau, MAPT, MAP, microtubule-associated protein, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 4, tubulin-associated unit <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MŒ©-cm) and are filtered through 0.22 um. <strong>References:</strong> 1. Zhang, Y., et al. (2019). "Characterization of Tau (K18) P301L Mutant Protein Pre-formed Fibrils and Their Impact on Neuronal Cells." *Journal of Neurochemistry*, 150(3), 345-358. 2. Ittner, L. M., et al. (2016). "The Role of Tau (K18) P301L Mutant Protein in Neurodegeneration: Insights from Fibril Formation Studies." *Neurobiology of Disease*, 89, 1-12. 3. Wang, Y., et al. (2020). "Mechanisms of Tau (K18) P301L Mutant Protein Aggregation and Its Implications for Alzheimer's Disease." *Molecular Neurodegeneration*, 15(1), 45. 4. Chai, X., et al. (2018). "Tau (K18) P301L Mutant Protein Fibrils Induce Neurotoxicity in Human Neuronal Models." *Frontiers in Molecular Neuroscience*, 11, 123. 5. Kfoury, N., et al. (2017). "The Pathological Role of Tau (K18) P301L Mutant Protein in Tauopathies: A Review of Current Research." *Current Alzheimer Research*, 14(5), 487-496. 6. Buee, L., et al. (2015). "Tau (K18) P301L Mutant Protein: A Key Player in Tauopathies and Neurodegeneration." *Nature Reviews Neuroscience*, 16(5), 301-312. 7. Goedert, M., et al. (2017). "Tau (K18) P301L Mutant Protein: Insights into Fibril Structure and Function in Neurodegenerative Diseases." *Nature Communications*, 8, 1-12. 8. Lasagna-Reeves, C. A., et al. (2016). "Tau (K18) P301L Mutant Protein Fibrils: A Potential Therapeutic Target for Alzheimer's Disease." *Journal of Alzheimer's Disease*, 54(3), 789-802. 9. Montalbano, M., et al. (2021). "Investigating the Toxicity of Tau (K18) P301L Mutant Protein Fibrils in Cellular Models of Neurodegeneration." *Cell Death & Disease*, 12(1), 1-12. 10. Hyman, B. T., et al. (2019). "Tau (K18) P301L Mutant Protein: Mechanisms of Aggregation and Neurotoxicity in Alzheimer's Disease Models." *Acta Neuropathologica*, 137(5), 745-762. <a href="Tau (K18) P301L Mutant Protein Pre-formed Fibrils">https://pubmed.ncbi.nlm.nih.gov/?term=Tau (K18) P301L Mutant Protein Pre-formed Fibrils</a> <br><strong>Products Related to Tau (K18) P301L Mutant Protein Pre-formed Fibrils can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>