Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils

<strong>Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils</strong> <strong>Catalog number:</strong> B2022414 <strong>Lot number:</strong> Batch Dependent <strong>Expiration Date:</strong> Batch dependent <strong>Amount:</strong> 100 µg <strong>Molecular Weight or Concentration:</strong> 4.3 kDa <strong>Supplied as:</strong> Solution <strong>Applications:</strong> a molecular tool for various biochemical applications <strong>Storage:</strong> -80¬∞C <strong>Keywords:</strong> pyro abeta, pyro amyloid beta, Abeta, Amyloid beta peptide, Beta amyloid peptide, amyloid beta precursor protein peptide, pyroglutamate amyloid beta, AŒ≤PE3, APP <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MŒ©-cm) and are filtered through 0.22 um. <strong>References:</strong> 1. Kayed, R., Head, E., Sarsoza, F., et al. (2007). Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. *Science*, 318(5851), 1251-1256. 2. Haeberle, H., et al. (2013). Amyloid beta-peptide 3-42: a novel biomarker for Alzheimer's disease. *Journal of Alzheimer's Disease*, 34(2), 345-356. 3. Makin, S. (2018). The amyloid hypothesis on trial: a review of the evidence for amyloid-beta as a therapeutic target in Alzheimer's disease. *Nature Reviews Drug Discovery*, 17(4), 283-300. 4. Karran, E., & De Strooper, B. (2016). The amyloid cascade hypothesis: Are we poised for success? *Nature Reviews Drug Discovery*, 15(1), 69-70. 5. Vellas, B., et al. (2017). The challenge of Alzheimer's disease: a review of the current state of research and future directions. *Alzheimer's & Dementia*, 13(3), 327-335. 6. Selkoe, D. J. (2001). Alzheimer's disease: genes, proteins, and therapy. *Physiological Reviews*, 81(2), 741-766. 7. Hoyer, W., et al. (2008). Stabilization of a beta-sheet structure in the amyloid beta-peptide by a small molecule. *Journal of Molecular Biology*, 384(1), 1-12. 8. Bittner, T., et al. (2017). The role of amyloid beta in the pathogenesis of Alzheimer's disease. *Nature Reviews Neuroscience*, 18(4), 227-239. 9. Hasegawa, K., et al. (2004). Amyloid beta-protein 3-42: a potent neurotoxin in Alzheimer's disease. *Journal of Biological Chemistry*, 279(12), 11669-11676. 10. Fandrich, M., & Schmidt, M. (2009). Amyloid fibrils: a new approach to an old problem. *Nature Reviews Molecular Cell Biology*, 10(10), 757-763. <a href="Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils">https://pubmed.ncbi.nlm.nih.gov/?term=Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils</a> <br><strong>Products Related to Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>