Antisauvagine-30
Potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist (Kd values are 1.4 and 153.6 nM for binding to mouse CRF2β and rat CRF1 receptors respectively) . Inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF2β cells (pA2 = 8.49) . Prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice in vivo.
Product Specifications
CAS Number
220673-95-0
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
3650.29
Molecular Formula
C161H274N48O46S
Notes
Research use only, not for human use.
Receptor
——
Available Sizes
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