Cyclotraxin B
Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM) . Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.
Product Specifications
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
1200.36
Molecular Formula
C48H73N13O17S3
Notes
Research use only, not for human use.
Receptor
——
CAS Number
1203586-72-4
Available Sizes
Curated Selection
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