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Huwentoxin IV

Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM) . Inhibits the channel by binding at the neurotoxin receptor site 4 in the S3-S4 linker of domain II, trapping the voltage sensor in the inward, closed configuration.

Product Specifications

CAS Number

526224-73-7

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

4106.79

Molecular Formula

C174H278N52O51S6

Notes

Research use only, not for human use.

Receptor

——

Available Sizes

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