K 41498
Potent and highly selective CRF2 receptor antagonist (Ki values are 0.66, 0.62 and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively) . Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. In rats in vivo, blocks urocortin-induced hypotension following systemic administration.
Product Specifications
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
3632.26
Molecular Formula
C162H276N48O46
Notes
Research use only, not for human use.
Receptor
——
CAS Number
434938-41-7
Available Sizes
Curated Selection
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