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OD1

Potent rat Nav1.7, human Nav1.4 and rat Nav1.6 channel activator (EC50 values are 7, 10 and 47 nM, respectively) . Exhibits minimal activation at mammalian Nav1.2, Nav1.3 and Nav1.5 (EC50 values >3 μM) . Inhibits fast inactivation on all channels. Increases peak currents at all voltages and stimulates a persistent Na+ current at hNav1.7 channel. Increases hyperpolarization at Nav1.4 and Nav1.6 channels. Induces spontaneous pain in vivo.

Product Specifications

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

7206.1

Molecular Formula

C308H466N90O95S8

Notes

Research use only, not for human use.

Receptor

——

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