R8-T198wt
Cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. Inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. Displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.
Product Specifications
CAS Number
2305815-72-7
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
2820.33
Molecular Formula
C111H211N59O26S
Notes
Research use only, not for human use.
Receptor
——
Available Sizes
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