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Fz7-21

Fz7-21 is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM) .

Product Specifications

CAS Number

2247635-23-8

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

1796.05

Molecular Formula

C83H114N18O23S2

Notes

Research use only, not for human use.

Receptor

EC50: 58 nM (human FZD7 CRD), 34 nM (mouse FZD7 CRD)

Available Sizes

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