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C 101248

C 101248 is a selective and potent inhibitor targeting both mouse and human tandem pore domain halothane-inhibited K+ channel 1 (THIK-1, IC50= 50 nM), without affecting the K2P family members (TREK-1, TWIK-2) and Kv2.1. This compound effectively blocks tonic and ATP-evoked THIK-1 K+ currents as observed in whole-cell patch-clamp recordings of mouse hippocampal microglia. Additionally, C 101248 mitigates neuroinflammation by inhibiting the NLRP3-dependent release of IL-1β in isolated microglia.

Product Specifications

CAS Number

361368-24-3

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

292.3

Molecular Formula

C15H12N6O

Notes

Research use only, not for human use.

Receptor

Others

Available Sizes

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