Amivantamab
Amivantamab (JNJ-61186372) is a humanized antibody that recognizes epidermal growth factor receptor (EGFR) and MET proto-oncogene (MET), with anticancer and anti-tumor activities, preventing ligand binding to EGFR and MET and receptor dimerization that inhibits downstream signal transduction. Amivantamab can induce Fc-dependent endocytosis of macrophages and antibody-dependent cytotoxicity of natural killer cells, and can be used to study metastatic non-small cell lung cancer.
Product Specifications
CAS Number
2171511-58-1
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
145.88 kDa.
Molecular Formula
——
Notes
Research use only, not for human use.
Receptor
C-Met/HGFR | EGFR
Available Sizes
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