RMC-6291
RMC-6291 is an orally active, covalent inhibitor of KRAS G12C (ON) that forms a tri-complex within tumor cells between KRAS G12C (ON) and cyclophilin A (CypA), thereby preventing KRAS G12C (ON) from signaling via steric blockade of RAS effector binding and eliciting deep and durable suppression of RAS pathway activity in KRAS G12C tumor models .
Product Specifications
CAS Number
2641998-63-0
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
1012.26
Molecular Formula
C55H78FN9O8
Notes
Research use only, not for human use.
Receptor
Kras
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