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FM04

FM04 is an orally active and highly potent inhibitor of P-glycoprotein (P-gp) with an EC50 value of 83 nM. FM04 can interact with Q1193 and I1115 in human P-gp nucleotide binding domain 2 (NBD2) . Thereby disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling the ICL2-NBD2 interaction, thereby inhibiting P-gp. FM04 can be used in the treatment of cancer and tumors.

Product Specifications

CAS Number

1807320-40-6

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

415.48

Molecular Formula

C26H25NO4

Notes

Research use only, not for human use.

Receptor

P-gp

Available Sizes

Frequently Asked Questions

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