BI-0474
BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antiproliferative activity against NCI-H358 cells harboring the G12C mutation, and shows significant anti-tumor activity in a non-small cell lung cancer xenograft model. activity.BI-0474 can be used for cancer research.
Product Specifications
CAS Number
2750570-55-7
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
587.74
Molecular Formula
C30H37N9O2S
Notes
Research use only, not for human use.
Receptor
Kras
Available Sizes
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