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BMS-903452

BMS-903452 is a potent and selective GPR119 agonist with an EC50 of 14 nM, indicated for the treatment of acute and chronic rodent diabetes. GPR119 is mainly expressed in pancreatic b cells and gastrointestinal endocrine cells. BMS-903452 shows no significant inhibitory effect on 9 cytochrome P450 enzymes (IC50 > 40 μM), does not activate PXR (EC50 > 50 μM), and is not toxic to liver (HEPG2) cell lines.

Product Specifications

CAS Number

1339944-47-6

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

513.37

Molecular Formula

C21H19Cl2FN4O4S

Notes

Research use only, not for human use.

Receptor

GPR

Available Sizes

Curated Selection

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