GSK-1482160
GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflammatory cytokines by central and peripheral immune cells, so GSK-1482160 has the potential to study inflammatory diseases. GSK-1482160 shows excellent in vitro potency (in functional and electrophysiological assays at recombinant and naive P2X7 receptors across multiple species including humans) and cross-target selectivity.
Product Specifications
CAS Number
1001389-72-5
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
334.72
Molecular Formula
C14H14ClF3N2O2
Notes
Research use only, not for human use.
Receptor
P2X Receptor
Available Sizes
Curated Selection
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