EM127
EM127 is a highly selective and potent covalent inhibitor of SMYD3 with a KD value of 13 μM.EM127 inhibits ERK1/2 phosphorylation and inhibits transcriptional regulation of SMYD3 target genes.EM127 slowly reduces methyltransferase activity over a long period of time.EM127 has potential anticancer activity and can be used to study SMYD3 positive tumors. EM127 has potential anticancer activity and can be used to study SMYD3 positive tumors.
Product Specifications
CAS Number
1886879-71-5
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
311.76
Molecular Formula
C14H18ClN3O3
Notes
Research use only, not for human use.
Receptor
Histone Methyltransferase | ERK
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
223383-01 50 µL
HSD17B2 (17 beta HSD 2, 17-beta-HSD 2, 17-beta-hydroxysteroid Dehydrogenase Type 2, 20 alpha HSD, 20 alpha hydroxysteroid Dehydrogenase, 20 alpha-hydroxysteroid Dehydrogenase, 20-alpha-HSD, DHB2_HUMAN, E2DH, EDH17B2, Estradiol 17-beta-Dehydrogenase 2, HSD17, Hsd17b2, Hydroxysteroid (17 beta) Dehydrogenase 2, Microsomal 17 beta hydroxysteroid Dehydrogenase, Microsomal 17-beta-hydroxysteroid Dehydrogenase, SDR9C2, Testosterone 17 beta Dehydrogenase, Testosterone 17-beta-Dehydrogenase, ) discontinued
Ask
View Details 
223383-02 100 µL
HSD17B2 (17 beta HSD 2, 17-beta-HSD 2, 17-beta-hydroxysteroid Dehydrogenase Type 2, 20 alpha HSD, 20 alpha hydroxysteroid Dehydrogenase, 20 alpha-hydroxysteroid Dehydrogenase, 20-alpha-HSD, DHB2_HUMAN, E2DH, EDH17B2, Estradiol 17-beta-Dehydrogenase 2, HSD17, Hsd17b2, Hydroxysteroid (17 beta) Dehydrogenase 2, Microsomal 17 beta hydroxysteroid Dehydrogenase, Microsomal 17-beta-hydroxysteroid Dehydrogenase, SDR9C2, Testosterone 17 beta Dehydrogenase, Testosterone 17-beta-Dehydrogenase, ) discontinued
Ask
View Details