RP-6685
RP-6685, a highly potent and selective inhibitor of DNA polymerase theta (Polθ), manifests remarkable oral activity. With an IC 50 value of 5.8 nM in the PicoGreen assay, RP-6685 effectively hinders the enzymatic activity of Polθ. In addition, it demonstrates significant antitumor efficacy as observed in a mouse tumor xenograft model .
Product Specifications
CAS Number
2832047-80-8
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
497.37
Molecular Formula
C22H14F7N5O
Notes
Research use only, not for human use.
Receptor
DNA/RNA Synthesis
Available Sizes
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