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PBRM1-BD2-IN-5

PBRM1-BD2-IN-5 is a potent inhibitor of the PBRM1 Bromodomain, with dissociation constant (Kd) values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5 respectively, and an inhibitory concentration 50 (IC50) value of 0.26 μM for PBRM1-BD2. This compound effectively diminishes the interaction between full-length PBRM1 and acetylated histone peptide within the PBAF complex in cell lysates, making it a promising candidate for anticancer research.

Product Specifications

CAS Number

2819989-61-0

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

272.73

Molecular Formula

C15H13ClN2O

Notes

Research use only, not for human use.

Receptor

Epigenetic Reader Domain

Available Sizes

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