GNE-064
GNE-064 is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 μM and inhibits SMARCA2 with an EC50 of 0.10 μM. GNE-064 possess Kds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of drug synthesis.
Product Specifications
CAS Number
1997321-20-6
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
327.38
Molecular Formula
C17H21N5O2
Notes
Research use only, not for human use.
Receptor
Epigenetic Reader Domain
Available Sizes
Curated Selection
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