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PA-8

PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vpac2 receptors. PA-8 also inhibited PacAP-induced elevation of cAMP levels in vitro (IC50 = 2 nM) and PacAP-induced aversive response and mechanical atopic pain after intrathecal injection in vivo.

Product Specifications

CAS Number

878437-15-1

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

342.35

Molecular Formula

C17H18N4O4

Notes

Research use only, not for human use.

Receptor

PACAP

Available Sizes

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