MI-3454
MI-3454 is an orally active, selective and potent inhibitor of Menin-MLL1 interaction that inhibits the proliferation and induces differentiation of acute leukemia cells with MLL1 translocation or NPM1 mutation.MI-3454 induces complete remission or regression of leukemia in a mouse model of leukemia with MLL1 rearrangement or NPM1 mutation through the down-regulation of key genes involved in leukemogenesis. complete remission or remission.
Product Specifications
CAS Number
2134169-43-8
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
636.73
Molecular Formula
C32H35F3N8OS
Notes
Research use only, not for human use.
Receptor
Histone Methyltransferase
Available Sizes
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