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Taletrectinib free base

Taletrectinib free base (AB-106 free base) is a novel potent, selective and orally active ROS1/NTRK inhibitor.Taletrectinib free base has potent inhibitory effects on recombinant ROS1, NTRK1, NTRK2, and NTRK3, with IC50s of 0.207, 0.622, 2.28 and 0.98 nM, respectively, Taletrectinib free base also inhibited ROS1 G2032R and other Crizotinib-resistant ROS1 mutations.

Product Specifications

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

405.47

Molecular Formula

C23H24FN5O

Notes

Research use only, not for human use.

Receptor

ROS Kinase

CAS Number

1505514-27-1

Available Sizes

Curated Selection

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