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Enpatoran hydrochloride

Enpatoran (M5049) hydrochloride is a potent, orally active dual inhibitor of TLR7/8 with IC50 values of 11.1 nM and 24.1 nM in HEK293 cells, respectively. This compound specifically inhibits TLR7 and TLR8 without affecting TLR3, TLR4, or TLR9, and blocks both synthetic molecule ligands and natural endogenous RNA ligands. Enpatoran hydrochloride also exhibits excellent pharmacokinetic properties in vivo, making it a valuable tool for studying and modulating innate and adaptive autoimmunity.

Product Specifications

CAS Number

2101945-93-9

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

356.78

Molecular Formula

C16H16ClF3N4

Notes

Research use only, not for human use.

Receptor

Others

Available Sizes

Frequently Asked Questions

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