Enpatoran hydrochloride
Enpatoran (M5049) hydrochloride is a potent, orally active dual inhibitor of TLR7/8 with IC50 values of 11.1 nM and 24.1 nM in HEK293 cells, respectively. This compound specifically inhibits TLR7 and TLR8 without affecting TLR3, TLR4, or TLR9, and blocks both synthetic molecule ligands and natural endogenous RNA ligands. Enpatoran hydrochloride also exhibits excellent pharmacokinetic properties in vivo, making it a valuable tool for studying and modulating innate and adaptive autoimmunity.
Product Specifications
CAS Number
2101945-93-9
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
356.78
Molecular Formula
C16H16ClF3N4
Notes
Research use only, not for human use.
Receptor
Others
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
bs-8689R-BF405 100 µL
MEPE Polyclonal Antibody, AbBy Fluor™ 405 Conjugated
Sign In for Pricing
View Details 
039548-FITC 200 µL
OVOS, NT (OVOS2, Ovostatin homolog 2) (FITC) discontinued
Sign In for Pricing
View Details abx441751 100 µg
Small Stress Protein-Like Protein HSP22 (HSP22) Antibody (ATTO 680)
Sign In for Pricing
View Details MBS2037827-01 0.1 mL
APC-Linked Polyclonal Antibody to Matrix Metalloproteinase 7 (MMP7)
Sign In for Pricing
View Details MBS2037827-02 0.2 mL
APC-Linked Polyclonal Antibody to Matrix Metalloproteinase 7 (MMP7)
Sign In for Pricing
View Details