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Endosidin-2

Endosidin-2 is an exocyst inhibitor, a cell-permeable benzylidene benzoylhydrazine, that binds to the exocyst component of the 70 kDa (EXO70) subunit of the exocyst complex (Kd = 253 μM, EXO70A1) .Endosidin-2 disrupts protein translocation between the endosomes and plasma membrane, thereby facilitating translocation of proteins to the vesicle for degradation. It also inhibits recirculation of endocytosed transferrin to the plasma membrane in HeLa cells and targets multiple isoforms of mammalian EXO70, leading to dysregulation of exocytosis.Endosidin2 can be used as a tool molecule to study cytosolization.

Product Specifications

CAS Number

1839524-44-5

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

414.17

Molecular Formula

C15H12FIN2O3

Notes

Research use only, not for human use.

Receptor

Others

Available Sizes

Frequently Asked Questions

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