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LC-2

LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a PROTAC that covalently binds KRAS G12C with MRTX849 and recruits the E3 ligase, VH, to induce a rapid and sustained degradation of KRAS G12C. LC-2 inhibits MAPK signaling in pure and heterozygous KRAS G12C cell lines.

Product Specifications

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

1132.78

Molecular Formula

C59H71ClFN11O7S

Notes

Research use only, not for human use.

Receptor

PROTACs

CAS Number

2502156-03-6

Available Sizes

Curated Selection

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