Erastin2
Erastin2 is a ferroptosis inducer and inhibitor of the system xc- cystine/glutamate transporter. It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 µM) and induces cell death in HAP1 cells at 5 µM, an effect blocked by ferrostatin-1 or deferoxamine. Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 µM), an effect blocked by β-mercaptoethanol (EC50 > 20 µM) . Additionally, it increases lipid peroxidation in HT-1080 cells at 1 µM.
Product Specifications
CAS Number
1695533-44-8
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
623.14
Molecular Formula
C36H35ClN4O4
Notes
Research use only, not for human use.
Receptor
Ferroptosis
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6407640-01 0.1 mL
ATM, Phosphorylated (S1981) (Ataxia Telangiectasia Mutated, AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1) (MaxLight 750)
Sign In for Pricing
View Details MBS6407640-02 5x 0.1 mL
ATM, Phosphorylated (S1981) (Ataxia Telangiectasia Mutated, AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1) (MaxLight 750)
Sign In for Pricing
View Details 