Erastin2

Erastin2 is a ferroptosis inducer and inhibitor of the system xc- cystine/glutamate transporter. It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 &#181M) and induces cell death in HAP1 cells at 5 &#181M, an effect blocked by ferrostatin-1 or deferoxamine. Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 &#181M), an effect blocked by β-mercaptoethanol (EC50 > 20 &#181M) . Additionally, it increases lipid peroxidation in HT-1080 cells at 1 &#181M.