Tenofovir exalidex
Tenofovir exalidex (CMX 157) is a lipid-conjugated acyclic nucleotide analog of Tenofovir, demonstrating efficacy against wild-type and antiretroviral-resistant HIV strains, including those resistant to multiple nucleoside/nucleotide analogs. It effectively inhibits all major HIV-1 and HIV-2 subtypes in fresh human PBMCs, as well as all evaluated HIV-1 strains in monocyte-derived macrophages, displaying EC50 values between 0.2 and 7.2 nM. Oral administration of CMX157 shows no apparent toxicity. Additionally, Tenofovir exalidex exhibits antiviral properties against HBV.
Product Specifications
CAS Number
911208-73-6
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
569.72
Molecular Formula
C28H52N5O5P
Notes
Research use only, not for human use.
Receptor
Antiviral
Available Sizes
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