Lecozotan HCl

Lecozotan HCl (SRA-333) is a potent and selective 5-HT antagonist that significantly enhances KCl-stimulated glutamate and acetylcholine release from the hippocampal dentate gyrus and has cognitive enhancing properties. Chronic administration of Lecozotan HCl did not induce 5-HT (1A) receptor tolerance or desensitization in a behavioral model demonstrating 5-HT (1A) receptor function.