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LE135

LE135 is a potent RAR antagonist that binds selectively to RARα (Ki of 1.4 μM) and RARβ (Ki of 220 nM), showing higher affinity for RARβ. It is highly selective over RARγ, RXRα, RXRβ, and RXRγ. LE135 also acts as a potent TRPV1 and TRPA1 receptor activator with EC50s of 2.5 μM and 20 μM, respectively.

Product Specifications

CAS Number

155877-83-1

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

438.56

Molecular Formula

C29H30N2O2

Notes

Research use only, not for human use.

Receptor

Retinoid Receptor

Available Sizes

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