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SB-505124 hydrochloride

SB-505124 hydrochloride (SB505124 hydrochloride) is an orally available, selective and potent inhibitor of TGF-β type I receptors (ALK4, ALK5, ALK7) with IC50 values of 129 nM and 47 nM for ALK4 and ALK5, respectively. SB-505124 hydrochloride inhibits IL-6 production by synovial explants and reduces Th17 differentiation in mice by decreasing Il17a and Rorc gene expression and IL-17 protein production.SB-505124 hydrochloride is used in the study of colorectal cancer.

Product Specifications

CAS Number

356559-13-2

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

371.86

Molecular Formula

C20H22ClN3O2

Notes

Research use only, not for human use.

Receptor

ALK

Available Sizes

Frequently Asked Questions

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