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Pladienolide B

Pladienolide B is a potent spliceosome inhibitor, a macrolide isolated from Streptomyces obtusususus Mer-12, which targets the SF3B1 subunit of the spliceosome.Pladienolide B exerts its antitumor effects by inhibiting pre-mRNA splicing and inducing necrosis.Pladienolide B possesses antitumor activity and can be used to study leukemia and lymphoid tumors. Pladienolide B has antitumor activity and can be used to study leukemia and lymphoid tumors.

Product Specifications

CAS Number

445493-23-2

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

536.7

Molecular Formula

C30H48O8

Notes

Research use only, not for human use.

Receptor

Apoptosis

Available Sizes

Frequently Asked Questions

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