Pladienolide B
Pladienolide B is a potent spliceosome inhibitor, a macrolide isolated from Streptomyces obtusususus Mer-12, which targets the SF3B1 subunit of the spliceosome.Pladienolide B exerts its antitumor effects by inhibiting pre-mRNA splicing and inducing necrosis.Pladienolide B possesses antitumor activity and can be used to study leukemia and lymphoid tumors. Pladienolide B has antitumor activity and can be used to study leukemia and lymphoid tumors.
Product Specifications
CAS Number
445493-23-2
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
536.7
Molecular Formula
C30H48O8
Notes
Research use only, not for human use.
Receptor
Apoptosis
Available Sizes
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